Create your PYDT game on the website and set your Game Settings…
Optional - PYDT Friendly or Club Rules Game
Optional - Advertise on the official PYDT discord
Once players have joined, start the game from the webpage.
Civilizations that players select, random or specific, need to be set as such in the setup of the actual game. (See tips below for more)
The save location is different on various computers or where Civilization is purchased from. The PYDT client shows your folder location. Open from the Options / Settings menu.
Players which are random on the game page. You may set a civilization for them when setting up the players in the hot seat settings. This is useful if you have your own random pool assignments.
You may have AI players.
All mods are supported. Ensure all players have access to mods, official or custom. PYDT does not care about mods. Here is a mod help page for Civ 6.
Mod-Manager setup and recommended mods
There are many other help and tips on various subjects in the Strategy Forum Channel.